for the defense and prevention of genetic mutations or viral attacks,which endanger the survival of the organism
When DNA damage occurs,the factors are activated by the environment surrounding the damaged cell,as information from other nearby cells,which they receive from the damaged cell,the information needed to prepare the rescue plan.The signaling of survival factors reach the damaged cell,activating the genetic resident control factor program.In DNA transcriptional and regulatory factors attempt rescue,seeking to repair the damage.Programmed cell death factors are activated via caspases,which are proteins that form a scaffold at the level of the cytosolic plasma membrane,and they act by activating a proteolytic cascade regulated by phosphorylations.Mitochondrial cytochrome c,released into cytosol,participates in activation of caspases.
Phosphatidylserine moves from the position inherent in the cytosolic plasma membrane,going outside on the extracellular plasma membrane,and it is formed as if it were a receptor with external signaling factor on the cell in view of the macrophages,which intercept the signal positioning themselves on the cell,then incorporate it and degrade it in their body.
Main causes leading to programmed cell death
caused by signaling factors that come from the external environment(magnetic radiation,reactive chemical compounds and gases).
such as Ros(highly reactive products of the partial reduction of O2,superoxide *O-2,minor byproduct of oxidative phosphorylation)
such as heat shock
Bioenergetic signaling mechanism of apoptosis
by animating metabolic cycles and therefore matter.
Through chemical-biological evolution,the cell has managed to develop a constitutive plan,animated by complex energy processes,where matter is transformed through energy by regulating and making the metabolic systems of living beings function.Matter to be animated by energy,there must be an internal order in living beings,which needs an energy supply to make it work. This is a thermodynamic plane,which must ensure sufficient availability of energy,which is supplied and then extracted from the matter that animates the surrounding Cosmos.
that keeps it away from a equilibrium that can bring it to a steady state,responsible for the decay of the matter.
Apoptosis is made necessary
consisting of a stationary-dynamic plane,which keeps away from the dynamic order of reactions
with a constant accumulation of mutations in the DNA,which the subsequent statistical increase in disease and cell senescence,directly proportional to the errors and damages that accumulate in the DNA or inside the macromolecules,regulated by biosynthesis.
Apoptosis & inflammation
that add up and are transmitted to the subsequent progeny of cells
and this is manipulated in such a way that the entire molecular composition amplifies a cascade of reactions,which reactions initiate a renewal of the tissue that leads to an apoptotic process
that makes the mechanism of survival and death factors more selective.The selective process,on the one hand with survival factors,triggers an attempt to rescue the cell from mutations that could endanger the organism.If this rescue attempt does not work within a set time,phosphatidylserine from the inside of the plasma membrane slides outwards,capturing the signals triggering a caspase cascade ends the life of the cell,which is directed towards apoptosis.
As it is well described in the article "Journal of Advanced Research".The homeostasis processes between anti-inflammatory and inflammatory factors are directly linked to lifestyle,and therefore aging itself is also an accumulation of mutations.The disease that makes its way first is aging,the general structure suffers irreversible damage.The problem is precisely to arrive in time before these damages are irreversible.For this reason,apoptosis is an essential concept for slowing down the senescence process.