Endopeel Chemistry: Molecular Precision for
Myoplasty, Myopexy, Myotension
& Lasting Firmness

Endopeel introduces a new dimension in aesthetic medicine based on molecular precision.
Its formulation, built around a stereochemically pure chiral acid, acts through controlled modulation of muscle tone rather than paralysis or volume effect.
This biochemical selectivity ensures reversible muscle tensioning, enhanced firmness, and complete tissue safety, without necrosis, atrophy, or inflammation.

Composition

Endopeel is a patented non-surgical formulation designed with molecular precision to safely induce controlled muscle tensioning. Its composition is based on a stereochemically pure aromatic acid associated with a refined lipid carrier system.

Core Components

Stereochemically pure aromatic acid
Chemically distinct from traditional phenolic derivatives, selected for its predictable acid–base profile (pKa ≈ 6.6) that ensures optimal compatibility with muscle tissue.
Refined peanut-oil phase
A purified lipid medium that modulates diffusion, improves tolerance, and facilitates homogeneous intramuscular distribution.
Esterified fatty acids
Provide chemical stability and consistent release at the target site.

What It Is Not

No volumizing fillers
No neuromodulators or paralytic agents
No cross-linked polymers or particulate implants

Safety-Focused Design

Enantiomeric specificity → selective, reversible biochemical interactions
Rapid elimination → no molecular accumulation in tissue
Tissue integrity preserved → no necrosis, atrophy, or inflammation when used per Endopeel protocol

Note: The Endopeel aromatic acid is a chemically distinct stereoisomer with a stable, safe molecular profile. It should not be confused with phenol or any of its industrial derivatives.

Main Ingredients

The Endopeel formulation combines a stereochemically pure aromatic acid with a refined lipid carrier derived from purified peanut oil and esterified fatty acids. This precise combination ensures controlled biochemical activity, rapid metabolism, and exceptional tissue safety.

Aromatic Acid Component

Simplified aromatic hydroxy acid molecular structure — Simplified aromatic structure with hydroxyl and carboxylic groups.
This stereochemically defined molecule is responsible for the selective biochemical action of Endopeel.

Acid–Base Behavior (pKa)

Henderson–Hasselbalch equilibrium of aromatic acid — Henderson–Hasselbalch equilibrium illustrating the balance between the protonated form (HA) and its conjugate base (A⁻). The aromatic acid used in Endopeel has a pKa ≈ 6.6, allowing **controlled ionization** near physiological pH and ensuring **stable, safe biochemical behavior** in muscle tissue.

This balanced acidity enables precise tissue compatibility and minimizes any risk of protein denaturation or irritation.

Refined Lipid Carrier

Lipid carrier phase derived from esterified fatty acids — A purified peanut-oil phase enriched with **esterified fatty acids**. It stabilizes the formulation and regulates the intramuscular diffusion of the active aromatic compound.

Summary

Stereochemically pure aromatic acid → defined, safe biochemical activity
pKa ≈ 6.6 → stable near physiological pH
Refined lipid carrier → improved tolerance and diffusion
No necrosis, atrophy, or inflammation when used per protocol
Rapid elimination → no molecular accumulation in tissue

Scientific References & Further Reading

Lipid Mediators and Anti-Aging Effects

Independent research shows that arachidonic acid and related lipid mediators participate in tissue remodeling, cell renewal, and anti-aging pathways of the skin — supporting the scientific relevance of lipid-based mechanisms in aesthetic medicine.

→ Read the referenced study

pKa & Tissue Safety

The acid dissociation constant (pKa) determines the ionization state of an acid at physiological pH (≈7.4). A lower pKa means a stronger acid and a more stable (weaker) conjugate base, favoring controlled, predictable behavior in tissue.

Compound	pKa	% Ionized at pH 7.4*	Conjugate Base	Interpretation
Endopeel aromatic acid	≈ 6.6	≈ 86%	More stable (weaker base)	Predictable, controlled ionization
Phenol (reference)	≈ 9.9	≈ 0.3%	Less stable (stronger base)	Mostly non-ionized at 7.4

*Estimated using Henderson–Hasselbalch: A⁻/HA = 10^(pH − pKa). At pH 7.4: for pKa=6.6 → ~86% ionized; for pKa=9.9 → ~0.3% ionized.

Why this matters: At physiological pH, the Endopeel aromatic acid remains largely ionized, which supports controlled interaction with proteins and predictable diffusion. In contrast, classical phenol stays mostly non-ionized at 7.4, increasing lipophilicity and non-selective membrane interactions—historical reason for tissue damage in inappropriate uses. Endopeel’s chemistry is designed to provide selective tensioning with tissue integrity preserved.

For Physicians (Henderson–Hasselbalch)

A⁻/HA = 10^(pH − pKa). Fraction ionized = A⁻/(A⁻+HA). The Endopeel aromatic acid (pKa ≈ 6.6) provides a favorable ionization ratio at pH 7.4, underpinning its predictable pharmacochemical profile and safety.

Stereochemistry & Enantiomeric Purity

Endopeel’s aromatic acid is a single, stereochemically pure enantiomer — a molecule that exists in one specific three-dimensional configuration. This chiral precision explains its selective biochemical activity and tissue safety, unlike racemic or non-chiral compounds such as traditional phenol.

Definitions of Key Terms in Stereochemistry

Stereoisomers: Same molecular formula, different 3D arrangement of atoms.
Enantiomers: Two stereoisomers that are non-superimposable mirror images.
Eutomer: Enantiomer with the desired/higher biological activity (Endopeel’s active isomer).
Distomer: The other enantiomer, lower or undesirable activity.
Racemate: 1:1 mixture of both enantiomers (less selective profile).
Chiral switch: Moving from a racemic drug to a single pure enantiomer to improve efficacy/safety.
Epimerization: Change at one stereocenter leading to a diastereomer (not enantiomer inversion).
Chiral inversion / racemization: In vivo interconversion of enantiomers.
(+) / (−) Optical isomers: Rotate plane-polarized light clockwise (dextrorotatory) / counter-clockwise (levorotatory).
(R) and (S) configurations: Absolute configurations per Cahn–Ingold–Prelog (right-/left-handed 3D arrangement).

Visualizing Enantiomeric (Non-Superimposable) Symmetry

Enantiomers as non-superimposable mirror images — Two enantiomers are **non-superimposable mirror images**. They share the same formula but differ in 3D orientation, which drives **specific receptor interactions** and **tissue selectivity**.

Why this matters: The Endopeel aromatic acid is not a generic phenolic compound but a defined chiral enantiomer. Only one spatial configuration binds reversibly to muscular and connective-tissue targets, ensuring predictable myotension with preserved tissue integrity.

Interactions – Implications for the Tissues

Molecule fits Receptor Site

Leading to a Response

Molecule doesnt fit Receptor Site

No Response

The chirality of Phenols

Phenols exhibit chirality within their molecules.

This chirality is due to the absence of planar and axial symmetry in the phenol molecule.

Scientific Definition

A molecule that is not superimposable is said to be chiral.

Ex :Left and right hands are mirror images but arent superimposable.

Chirality For Dummies

Chemically Similar but Structurally Different

Hitler was a criminal nazi and Chaplin was a comic Jew

Conclusion

Enantiomers of phenol will interact with the skin and muscles differently

The enantiomers of phenol are similar by their formula but their shape is different .
Like a key in a lock,only the chirally correct form ( here the endopeels phenic acid) can interact with the appropriate cell receptor and trigger the right cellular response.
The ,,wrong,, form of the phenol can collect on the skin s surface and can cause necrosis and big edema.

Ignorance & Prejudges

Einstein used to say that it was easier to break an atome than to break prejudges.

We do not have the right to open our mouth if our mind is close.

Courteline :

in french :
Passer pour un idiot aux yeux d un imbécile est un plaisir de fin gourmet.

Translated into english:
Look like an idiot in the eyes of a fool is a fun foodie

Endopeel Chemistry: Molecular Precision for
Myoplasty, Myopexy, Myotension
& Lasting Firmness

Endopeel Chemistry: Molecular Precision for
Myoplasty, Myopexy, Myotension
& Lasting Firmness